ToxPi : Toxicological Prioritization Index

Download free interface


The ToxPi interface is distributed as a single compressed .zip download. It includes the latest version of the main Java executable, all libraries, example data files, and a complete user manual. This distribution is free, under the GNU GPL.

Download (August 2019 Update):

Download User Manual Only: ToxPi User Manual.pdf

Visual analytics for your data

Dynamic exploration, visualization, and sharing of integrated data models


Integrate multiple sources of evidence by transforming data into visual profiles


Cluster profiles into similarity neighborhoods

Dynamic Exploration

Explore any type of data with flexible input formats, then customize models

Share Complete Models

Share input data, complete models, and publication-quality graphics with collaborators

Published ToxPi Applications



Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics. 2018 Mar 5;19(1):80.

Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RF. Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environmental Health Perspectives. 2010. 118(12):1714-20.

GUI Development Funded by EPA STAR Center #R835802 (Rusyn, Wright, Grimm) and NIH ES025128 (Marvel, Reif)

Explore ongoing work (including a new toxpiR package and GIS Toolkit) using the ToxPi framework: